Dr. Simpson earned B.S., M.S., and Ph.D. degrees in Electrical Engineering from the University of Tennessee in 1983, 1987, and 1991, respectively. His dissertation research focused on charge trapping correction in high-purity germanium radiation detectors. At the time he received his Ph.D. Simpson worked in R&D at EG&G Ortec, and moved to the Scientific Staff of the Oak Ridge National Laboratory in 1992 where he initially worked on the design of high-speed, custom, analog, integrated circuits for collider physics experiments. Later Simpson’s research interest focused more on nanoscale structures, and in particular, on the interface between nanoscale devices and biological systems. Simpson is now a Distinguished Research Staff Member and Theme Leader in the ORNL Center for Nanophase Materials Sciences. Dr. Simpson began a joint faculty appointment with the University of Tennessee in 1993, first with the Electrical and Computer Engineering Department, and now with the Materials Science and Engineering Department, where he teaches nanobiosciences courses and performs research at the physical-biological sciences boundary. Dr Simpson has authored or co-authored 115 peer reviewed journal papers, holds 24 U.S. Patents, and has presented numerous invited talks at conferences, workshops, and symposia.
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Ph.D., Tennessee: Semiconductor devices and analog electronic circuits
Co-Chair and IEEE-EMBS representative for the second Bio-, Micro-, and Nanosystems Biology Conference sponsored by the American Society of Microbiology and IEEE-EMBS, January 15-18, 2006.
Co-Chair and IEEE-EMBS representative for the first Bio-, Micro-, and Nanosystems Biology Conference sponsored by the American Society of Microbiology and IEEE-EMBS, July 7-10, 2003.
Member of the Advisory Committee for the Georgia Tech Conference on Nanosciene and Nanotechnology, 2001
Member of the Advisory Committee for the Georgia Tech First Conference on Nanosciene and Nanotechnology, October 2000
Awards and Recognitions
2007 Named a Battelle Memorial Institute Distinguished Inventor
1998 Kermit Fischer Environmental Award for the Pioneering Development of an Integrated CMOS Photo-Spectrometer for Wide Applications including Environmental Monitoring.
1998 Finalist for a Discover Magazine Technology Innovation award for the development of the Bioluminescent Bioreporter Integrated Circuit.
1998 Awarded Lockheed-Martin Energy Research Corporation Medal for Excellence in Technical Achievement, for the co-development of a deep submicron lithography method.
1998 Awarded Lockheed-Martin Energy Research Corporation Medal for Excellence in Technical Achievement for the co-development of an integrated circuit for a collider detector application.
1997 Awarded Lockheed-Martin Energy Research Corporation Medal for Excellence in Technical Achievement for the development of a single-chip photo-spectrometer.
M. J. Doktycz and M. L. Simpson, “Nano-enabled synthetic biology,” Mol Syst Biol, vol. 3, 2007.
M. L. Simpson “Cell-free synthetic biology: a bottom-up approach to discovery by design,” Mol. Syst. Biol., vol. 2, 2006.
Austin, D. W., M. S. Allen, J. M. McCollum, R. D. Dar, J. R. Wilgus, G. S. Sayler, N. F. Samatova, C. D. Cox, & M. L. Simpson, “Gene Network Shaping of Inherent Noise Spectra”, Nature 439, Feb. 2, 2006, 608-611.
Melechko, A.V., V.I. Merkulov, T.E. McKnight, M.A. Guillorn, K.L. Klein, D.H. Lowndes, and M.L. Simpson. “Vertically aligned carbon nanofibers and related structures: Controlled synthesis and directed assembly.” J. Appl. Phy., 97(4), Feb. 15, 2005, 041301-39.
Fletcher, B. L., E. D. Hullander, A. V. Melechko, T. E. McKnight, K. L. Klein, D. K. Hensley, J. L. Morrell, M. L. Simpson, M. J. Doktycz. “Microarrays of biomimetic cells formed by the controlled synthesis of carbon nanofiber membranes.” Nano Letters 2004,4(10), October 2004, 1809-1814.
M. L. Simpson, C.D. Cox, and G.S. Sayler, “Frequency domain chemical Langevin analysis of stochasticity in gene transcriptional regulation”. J. Theo. Bio. 229(3), August 2004, 383-394.
McKnight, T. E., A. V. Melechko, G. D. Griffin, M. A. Guillorn, V. I. Merkulov, F. Serna, D. K. Hensley, M. J. Doktycz, D. H. Lowndes, and M. L. Simpson. “Intracellular integration of synthetic nanostructures with viable cells for controlled biochemical manipulation.” Nano Letts. 4(7); July 7, 2004, 1213-1219.
M. L. Simpson, C. D. Cox, G. D. Peterson, and G. S. Sayler. “Engineering in the Biological Substrate: Information Processing in Genetic Circuits.” Proc. IEEE. Vol. 92(5), May 2004, 848-863.
M.L. Simpson, M. J. Paulus, G. S. Sayler, B. M. Applegate, S. A. Ripp. Patent Number 7,208,286 “Bioluminescent bioreporter integrated circuit devices and methods for detecting ammonia”.
M. L. Simpson, M. J. Paulus, G. S. Sayler, B. Applegate, S. Ripp. Patent Number 7,090,992 “Bioluminescent bioreporter integrated circuit devices and methods for detecting estrogen”.
M. L. Simpson, M. J. Paulus, G. S. Sayler, B. M. Applegate, S. A. Ripp. Patent Number 6,905,834. “Bioluminescent bioreporter integrated circuit detection methods”.
M. L. Simpson, D. H. Lowndes, V. I. Merkulov, M. A. Guillorn, and C. L. Britton. Patent Number 6,692,324. “Single Self-Aligned Carbon Containing Tips”.
M. L. Simpson, G. S. Sayler, and M. J. Paulus. Patent Number 6,117,643 “Bioluminescent Bioreporter Integrated Circuit”.
M. L. Simpson, M. N. Ericson, G. E. Jellison, A. L. Wintenberg, W. B. Dress, and D. N. Sitter. Patent Number 5,965,873 , “Photo-Spectrometers, Method of Use and Manufacture”.
M. L. Simpson and T. W. Raudorf. Patent Number 4,937,452, “Charge Trapping Correction in Photon Detection Systems”.